diff --git a/mysql.spec b/mysql.spec
index 828d0348be09f9c8b19de12201440c7d3def5620..958ce71fd5abb2b3a74c04f2028a5bccbdf74251 100644
--- a/mysql.spec
+++ b/mysql.spec
@@ -72,7 +72,7 @@
 Summary:          MySQL client programs and shared libraries
 Name:             mysql
 Version:          8.0.45
-Release:          1%{?with_debug:.debug}%{?dist}
+Release:          2%{?with_debug:.debug}%{?dist}
 License:          GPL-2.0-or-later AND LGPL-2.1-only AND BSL-1.0 AND BSD-2-Clause
 URL:              http://www.mysql.com
 Source0:          https://cdn.mysql.com/Downloads/MySQL-8.0/mysql-boost-%{version}.tar.gz
@@ -351,6 +351,8 @@ cp %{SOURCE1} %{SOURCE10} %{SOURCE11} %{SOURCE12} \
          -DREPRODUCIBLE_BUILD=OFF \
          -DCMAKE_C_FLAGS="%{optflags}%{?with_debug: -fno-strict-overflow -Wno-unused-result -Wno-unused-function -Wno-unused-but-set-variable}" \
          -DCMAKE_CXX_FLAGS="%{optflags}%{?with_debug: -fno-strict-overflow -Wno-unused-result -Wno-unused-function -Wno-unused-but-set-variable}" \
+         -DCMAKE_C_FLAGS_RELWITHDEBINFO:STRING="%{optflags} -g -DNDEBUG" \
+         -DCMAKE_CXX_FLAGS_RELWITHDEBINFO:STRING="%{optflags} -g -DNDEBUG" \
          -DCMAKE_EXE_LINKER_FLAGS="-pie %{build_ldflags}" \
 %{?with_debug: -DWITH_DEBUG=1} \
 %{?with_debug: -DMYSQL_MAINTAINER_MODE=0} \
@@ -833,6 +835,10 @@ fi
 %endif
 
 %changelog
+* Tue Mar 24 2026 xionghuluo <xionghuluo@tencent.com> - 8.0.45-2
+- [Type] enhancement
+- [DESC] Pass CMAKE_C_FLAGS_RELWITHDEBINFO / CMAKE_CXX_FLAGS_RELWITHDEBINFO to align RelWithDebInfo flags with %{optflags} (-g -DNDEBUG) for PGO/instrumented builds
+
 * Wed Jan 28 2026 Wang Guodong <gordonwwang@tencent.com> - 8.0.45-1
 - Upgrade to 8.0.45
 - fix CVE-2026-21936, CVE-2026-21937, CVE-2026-21941, CVE-2026-21948, CVE-2026-21964,